ABSTRACT
Objective: The purpose of this study is; firstly, to find out the prevalence of drug resistant Acinetobacter baumannii, secondly, to find the most common site of infection by Acinetobacter baumannii, and thirdly, to assess the in vitro effectiveness of tigecycline against drug resistant Acinetobacter baumannii, in our hospital setting
Study Design: Retrospective/Observational study
Setting: Charsada Teaching Hospital affiliated with Jinnah Medical College Peshawar
Period: One year from January 2016 to December 2016
Methodology: All the reports occurring during this study period with positive diagnosis for Acinetobacter were retrieved from the archives, irrespective of patient's age and gender. Only one isolate of Acinetobacter per patient was considered in the study. The organisms were identified and species determined manually. Susceptibility for antimicrobial agents was determined according to criteria of CLSI 2016. MIC for tigecycline in the isolates was determined by E-test
Results: On analyzing all the Acinetobacter isolates [n=391] during one year time, it was found that the large majority of these isolates were of Acinetobacter baumannii [96.2%], while only few were of Acinetobacter lwoffii [3.8%]. Multidrug resistant Acinetobacter baumannii represented about one third [31%] of all the Acinetobacter baumannii isolates. Most of the isolates of Acinetobacter baumannii were from skin and soft tissue wounds [44.4%], followed by isolates from respiratory secretions [42.7%], urine [6.8%], blood [5.2%] and CSF [0.9%] [Table II]. The isolates of Acinetobacter baumannii showed maximum sensitivity to Tigecycline [88.9%], followed by Colistin [81.2%] and Polymyxin [79.5%] [Table III]
Conclusions: Drug resistant Acinetobacter baumannii is present in 31% of isolates, it is most commonly isolated from infected wounds and respiratory tract secretions in debilitated patients, and also Tigecycline is an excellent treatment choice for infections caused by drug resistant Acinetobacter baumannii
ABSTRACT
Objective: The purpose of this study is, firstly, to find the pattern of ear diseases in the community, as no such pattern study is currently available. Secondly, to impart awareness regarding microscopic appearances of the common ear diseases encountered in this pattern study
Study Design: Observational / descriptive study
Place and Duration of Study: This study was conducted at the Surgical Pathology archives of the Laboratory of Charsada Teaching Hospital affiliated with Jinnah Medical College Peshawar from 2010 to 2015
Materials and Methods: In this study, all the cases of ear diseases from surgical pathology archives of the laboratory of Charsada Teaching Hospital were retrieved. All the slides and the diagnoses for the retrieved cases were reviewed by the histopathologist and the final diagnoses were recorded; the disease pattern was determined, keeping in view the number of cases for each diagnostic category and the patient's age
Results: The review of these cases between 2010 and 2015 showed that most of the biopsy specimens were from external ear while few were from the middle ear. The first five commonest conditions constituted almost two thirds of the total number of cases. The congenital anomalies and juvenile xanthogranulomas were most common in the first decade of life. Benign and malignant tumors were uncommon and seen mostly after the third decade of life
Conclusions: Congenital anomalies and inflammation associated diseases are common in the first three decades of life, whereas benign and malignant neoplasms are more common after the third decade of life
ABSTRACT
To identify the clinical behaviour and consequences of cholesteatoma and to formulate a strategy for achieving early diagnosis, appropriate management and avoidance of all the grave complications. Hospital based descriptive type of study. This study was conducted in Shahina Jamil Hospital from April 2011 to Dec 2012. 40 patients of any age and gender were included in the study. The age, gender, socio-economic status and complications like hearing loss, facial nerve paralysis, intracranial spread, labyrinthitis, mastoid fistula and ossicular chain status were recorded and analyzed. We found that 62.5% were male and 37.5% were female.75% of the patients belong to rural areas and 25% belong to urban areas. All the patients [100%] presented with ear discharge and hearing loss. Ossicles were found intact in all patients. Labyrinthitis was the most common complication [37.5%]. It was found that cholesteatoma was frequent among poor, male and young patients leading to necrosis of the ossicles in all patients. Labyrinthitis, mastoid fistula and intracranial spread were common complication